Combining Flea Treatments – What You Need To Know?

When it comes to mixing treatments you must be aware of the combination of treatments that go well with each other. However, make sure, any such practice should be avoided without having proper supervision. Well, there are many good flea treatments in topical, spot-on, orals and chews that are highly effective in stopping the infestation. But at times, a product that suits one pet may not suit the other pet which is why it is important to consider the vet’s advice.

To find the right combination of treatments, you must refer to the product labels. Products that treat fleas alone are generally safe to combine with treatments that only work against ticks. Here are some of the combinations that you can try.


combine capstar with frontline plus

Oral flea treatments like Capstar which kills only adult fleas can be combined with Frontline Plus as well as Revolution. All of these products not only kill juvenile forms of fleas but also eliminate ticks for a month.

combine frontline plus with heartgard plus

It is extremely necessary to protect your pet against the deadly heartworm disease but it is also important to treat him/her with the right products. So, in case your furry kid has a flea infestation and you want a safe heartwormer as well, you can combine Frontline Plus with Heartgard Plus. Heartgard Plus is a powerful dewormer that not just provides protection against heartworms but also kills roundworms and hookworms. You can also combine Nuheart with Frontline Plus.

combine preventic collar with frontline plus

A few of the flea collars like Preventic Tick Collar or Scalibor Collars that are effective in treating ticks can be combined with Frontline Plus, Frontline Original or Advantage Multi. In case you are using Seresto Collar, you must consult your vet before combining it along with some other product.

Combinations That Must Not Be Used

Frontline Plus with Advantage II

Revolution with Advocate (Advantage Multi)

Frontline Plus or Top Spot with Advantix/Advantage

Points To Remember…
  • Never overdose your pet with any treatment. Consult your vet in case of any confusion.
  • Do not combine treatments that target the same parasites.
  • Do not use more than one spot on treatment, no two oral treatments or heartworm pills.


Combining two products is fine if you know the reaction of ingredients with each other. However, it is suggested that you must consult your vet before doing so. It is better that you go for broad-spectrum treatments that are manufactured specifically to treat multiple parasitic infections with one product. Moreover, that will also save you money. You can always purchase these products online at rather lower prices but do consult the vet.



This blog is just for information purposes; please contact your vet before starting any treatments.