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Interceptor Plus and Simparica Trio – Which One is Better?

Interceptor Plus vs Simparica Trio

Parasites like fleas, ticks, heartworms, intestinal worms, etc make the life miserable for your canine companions. As a loving and caring pet parent, you need to be on your toes, all the time, to protect them from these mighty insects. And the ocean of treatment options doesn’t make it any easier. The veterinary market is flooded with antiparasitics, always leaving you in a dilemma as to which one to go with.

We understand this well and this is why we have come up with a couple of popular parasitic treatments that may help you choose one for your four-foot friend. Interceptor Plus and Simparica Trio have been in demand for some time now. Both these products have so much to offer.

This blog provides a thorough comparison of these two products, serving with everything you need to know about them, so that you can choose the best suitable product for your dog. Read through to learn more.

About Simparica Trio and Interceptor Plus

Simparica Trio for dogs is a flavored broad-spectrum chewable treatment for dogs. This monthly formula is indicated for use in 8 weeks and older puppies and dogs.

Interceptor Plus for dogs is a multi-worm protection for 6 weeks and older puppies and dogs. This palatable flavored treatment protects dogs against all five major worms including heartworms for one month.

Interceptor Plus and Simparica Trio – Offered Protection

Interceptor Plus for dogs prevents heartworm disease. Moreover, it treats and controls a variety of gastrointestinal worm infections including roundworms, hookworms, whipworms and tapeworms for one month.

On the other hand, Simparica Trio for dogs kills adult fleas as well as treats and prevents flea infestations. It prevents heartworm disease caused by Dirofilaria immitis; treats and controls roundworm and hookworm infections. This formula also treats and controls Gulf coast tick, lone star tick, black-legged tick, American dog tick and Brown dog tick infestations. Due to its black-legged tick killing ability, Simparica Trio is also known to prevent Lyme disease.

Key Differences Between Simparica Trio and Interceptor Plus

Minimum Age and Weight

Simparica Trio is recommended for use in 8 weeks and older puppies and dogs, weighing 2.8 lbs or more; whereas Interceptor Plus is safe for 6 weeks or old age group puppies and dogs that weigh 2 lbs or more.


Simparica Trio and Interceptor Plus are made with different compositions. Simparica Trio contains sarolaner, moxidectin and pyrantel as active components; whereas Interceptor Plus comprises milbemycin oxime and praziquantel.

Chew Flavor

Interceptor Plus offers real chicken flavor. On the other hand, Simparica Trio is made in a palatable liver flavor chewable.

Gain further understanding about : Simparica Trio Recall 2022

Differences in Worm Protection

Interceptor Plus protects against all major worms and it is safe to use on both young puppies and older dogs. It is probably the only treatment that protects dogs against all five major worms, i.e. heartworms, roundworms, hookworms, whipworms and tapeworms. In addition, Interceptor Plus also lets you protect your puppies as young six weeks of age and older.

Simparica Trio is a combination of three ingredients, i.e. sarolaner, moxidectin and pyrantel. Two of these ingredients (moxidectin and pyrantel) jointly protect against three types of worms including heartworms, roundworms and hookworms. If heartworms along with roundworms and hookworms are your concern, you can consider using Simparica Trio.

Read More: Intestinal Worms In Dogs: Things You Need To Know

Simparica Trio and Interceptor Plus Comparison Table

The table below provides an extensive comparison of product features offered by both Simparica Trio and Interceptor Plus:

Which One to Choose – Simparica Trio or Interceptor Plus

Considering the composition, Interceptor Plus and Simparica Trio, both are equally safe and reliable treatments.

Either of these treatments is equally efficient in protecting dogs from heartworms, roundworms, and hookworms.

If fleas and ticks, along with heartworms and intestinal worms are your concern, Simparica Trio is the one. In case, your dog is already taking other flea and tick treatment, and you only want heartworm and intestinal worm protection including whipworms, consider Interceptor Plus.

In any case, it is always recommended to consult with a veterinarian before administering any treatment on your four-foot companion.

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